MEZENTSEV, Alexandre V.

Center for Radiological Research, Columbia University

NAME AND POSITION TITLE

Alexandre V. Mezentsev
Research Associate Scientist

CONTACT INFORMATION:

Postal address:

Columbia University,
Center for Radiological
Research
630 West, 168th Street
room. 11-215
New York, NY 10032

Phone:

(212) 305-39-11

Fax:

(212) 305-3229

E-mail:

am2710@columbia.edu

INSTITUTION AND LOCATION

DEGREE

YEARS

FIELD OF STUDY

Russian Academy of Sciences, Institute of Biochemistry, Moscow, Russia

Ph.D.

1996

Biochemistry

Moscow State University, Moscow, Russia

M.S.

1991

Biochemistry

1.

Geng S., Mezentsev A., Kalachikov S., Raith K., Roop D. and Panteleyev A. Targeted ablation of Arnt in mouse epidermis results in profound deffects in desquamation and epidermal barrier function (2006) J Cell Sci. 119(23), P4901-12.

2.

Mezentsev A, Mastyugin V, Ashkar S, Seta F, Reddy S, Falck JR and Laniado-Schwartzman M. Transfection CYP4B1 into the cornea increases angiogenic activity of the limbal vessels (2005) J Pharmacol Exp Ther. 315(1), P42-50.

3.

Mezentzev A, Merks RMH., O’Riordan E, Chen J, Mendelev N, Goligorsky MS and Brodsky SV. Endothelial microparticles affect angiogenesis in vitro: the role of oxidative stress. (2005) Am J Physiol Heart Circ Physiol. 289(3), H1106-14

4.

Li Volti G, Sacerdoti D., Sangras B, Vanella A, Mezentsev A, Scapagnini G, Falck JR and Abraham N. Carbon monoxide signaling in promoting angiogenesis in human microvessel endothelial cells (2005) Antioxidants and Redox Signal. Vol. 7, N5-6, P. 704-710.

5.

Mastyugin V, Mesentsev A, Wen-Xiang Zhang, Ashkar S, Dunn MW and Laniado- Schwartzman M. Promoter activity and regulation of the corneal CYP4B1 gene by hypoxia. (2004) J. Cell. Biochem. Vol. 91, N6, P.1218-38

6.

Ashkar S, Mesentsev A, Wen-Xiang Zhang, Mastyugin V, Dunn MW and Laniado- Schwartzman M Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroeicosanoids (2004) J. Cell. Pharm. Therapeutics, Vol. 20, N1, P.65-74

7.

Jiang M, Mesentsev A, Byun K, Falck JR, Miano JM, Abraham NG and Laniado- Schwartzman M. Smooth muscle-specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels (2004) Circ. Res. Vol. 94, N2, P.65-74

8.

Laniado- Schwartzman M, Bonazzi A, Mieyal P, Mesentsev A, Abraham NG and Dunn MW. COX-2 lack of function in hypoxia-induced ocular surface inflammation (2003) Thrombosis Res. (2003) Vol. 110 N 5-6, P. 293-298

9.

Mezentsev AV, Seta F, Dunn, MW, Ono N, Falck, JR and Laniado-Schwartzman M. The angiogenic activity of 12(R)-hydroxyeicosatrienoic acid is mediated by vascular endothelial growth factor (VEGF). (2002) J. Biol. Chem. Vol. 277, N21, P.18670-18676

10.

Malaguarnera L, Pilastro MR, Quan S, Ghattas MH, Yang L, Mezentsev AV, Kushida T, Abraham NG and Kappas A. Significance of heme oxygenase in prolactin- mediated cell proliferation and angiogenesis in human endothelial cells. Int. J. Mol. Med. (2002) Vol. 10, N4, P.433-40.

11.

Galkin AG, Kutsenko AS, Bajulina NP, Esipova NG, Lamzin VS, Mesentsev AV, Shelukho DV, Tikhonova TV, Tishkov VI, Ustinnikova TB and Popov VO. Site-directed mutagenesis of the essential arginine of the formate dehydrogenase active centre. (2002) Biochim. Biophys. Acta. Vol. 1594, N1 P.136-49

12.

Vinogradova MV, Mezentsev AV, Lukong KE, El-Alfy M, Morales CR, Michaud L and Pshezhetsky AV. Molecular mechanism of the sialidase deficiency in galactosialidosis involves its rapid degradation. (1998) Biochem. J., Vol. 330, N2, P.641-650

13.

Mesentsev AV, Lamzin VS, Tishkov VI, Ustinnikova TB and Popov VO. Effect of pH on kinetic parameters of NAD-dependent formate dehydrogenase. (1997) Biochem. J. Vol. 321, P. 475-480

14.

Tishkov VI, Matorin AD, Rojkova AM, Fedorchuk VV, Savitsky PA, Dementieva LA, Lamzin VS, Mesentzev AV and Popov VO. Site-directed mutagenesis of the formate dehydrogenase active centre: role of the His332-Gln313 pair in enzyme catalysis. (1996) FEBS Lett. Vol. 390, P. 104-108

15.

Mezentsev AV, Ustinnikova TB, Tikhonova TV and Popov VO. Isolation and kinetic mechanism of action of NAD- dependent formate dehydrogenase from methylotrophic yeast Hansenula polymorpha. (1996) Applied Biochemistry and Microbiology (Moscow) Vol. 32, N 6, P. 850-854

1.

Geng S., Mezentsev A., Miho I, Kalachikov SM. and Panteleyev AA. The Role of Arnt gene in Perinatal Mouse Skin Neovascularization. Society for Investigative Dermatology Annual Meeting (2006) J. Invest. Derm. 126, S4, P.4

2.

Mezentsev A, Kalachikov SM. and Panteleyev AA. Regulation of Epidermal Late- Differentiation Genes via Arnt-dependent Pathway in Primary Mouse Keratinocytes Requires Chromatin Remodeling. Society for Investigative Dermatology Annual Meeting (2006) J. Invest. Derm. 126, S4, P.69

3.

Mezentsev A, Kalachikov SM. and Panteleyev AA. The Patterns of Periderm Shedding in Mice and the Role of Arnt in Regulation of This Process. Society for Investigative Dermatology Annual Meeting (2006) J. Invest. Derm. 126, S4, P.69

4.

Mezentsev A, Seta F, Kemp R, Dunn MW and Laniado-Schwartzman M. The Corneal epithelial CYP4B1 produces angiogenic eicosanoids and induces inflammation of the ocular surface (2005) ARVO, Program Summary Book

5.

Seta F, Mezentsev A, Dunn MW and Laniado-Schwartzman M. The corneal-derived 12(R)-hydroxyeicosatrienoic acid (12-HETrE) stimulates IL-8 production in microvessel endothelial cells  (2005) ARVO, Program Summary Book

6.

Laniado-Schwartzman M, Mezentsev A, Seta F, Dunn MW, Abraham NG and Gronert K Heme Oxygenase-2 (HO-2) Knockout Mice Display Impaired Corneal Wound Healing and Marked Corneal Neovascularization (2005) ARVO, Program Summary Book

7.

Mezentsev A, Mastyugin V, Ashkar S, Seta F, Reddy S, Falck JR and Laniado-Schwartzman M. Transfection CYP4B1 into the cornea increases angiogenic activity of the limbal vessels (2005) The 7th Annual Winter Eicosanoid Conference, Program Summary Book.

8.

Seta F, Mezentsev A, Dunn MW, Gronert K, Abraham NG, and Laniado-Schwartzman M. Heme oxygenase-2 (HO-2) null mice impaired corneal wound healing and marked neovascularization (2005) The 7th Annual Winter Eicosanoid Conference, Program Summary Book.

9.

Mezentsev A, Seta F, Dunn MW and Laniado-Schwartzman M. Transfection of CYP4B1 into the cornea induces angiogenic activity in the limbal vessels. (2004) ARVO, Program Summary Book

10.

Seta F, Mezentsev A, Dunn MW and Laniado-Schwartzman M. Corneal-derived 12(R)-hydroxyeicosatrienoic acid (12-HETrE), stimulates limbal endothelial angiogenesis via Erk1/2 independent of Ras/Raf activation. (2004) ARVO, Program Summary Book

11.

Jiang M, Mezentsev A, Kemp R, Byun K, Falck JR, Miano J, Nasjletti A, Abraham NG and Laniado-Schwartzman M. Smooth muscle-specific expression of CYP4A1 induces endothelial sprouting in renal arterial microvessels (2004) AAPS National Biotechnology Conference The Westin Copley Place, Boston, MA

12.

Mezentsev AV, Zhang W-X, Mastyugin V, Dunn, MW and Laniado- Schwartzman, M. Promoter activity and regulation of the corneal CYP4B1 gene by hypoxia (2003) ARVO, Program Summary Book, P. 35

13.

Seta F, Mezentsev A, Ashkar S, Dunn MW and Laniado-Schwartzman M. Angiogenic properties of the corneal epithelial metabolite 12(R)- hydroxyeicosatrienoic acid (12(R)-HETrE) in human microvessel endothelial cells. (2003) ARVO, Program Summary Book, P.94.

14.

Ashkar SC, Zhang W-X, Mezentsev AV, Mastyugin V, Dunn MW and Laniado- Schwartzman M. Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids. (2003) ARVO, Program Summary Book, P. 35.

15.

Sack R, Sathe S, Laniado- Schwartzman M, Mesentsev A and Morris C. Closed eye tear fluid contains a potent high molecular weight angiogenic factor. (2003) ARVO, Program Summary Book, P. 57.

16.

Seta F, Mezentsev A, Dunn MW and Laniado-Schwartzman M. 12(R)-hydroxyeicosatrienoic acid, a corneal epithelial derived eicosanoid, stimulates angiogenesis via Erk1/2 activation of VEGF induction. (2002) ARVO, Program Summary Book.

17.

Laniado-Schwartzman M, Mezentsev A, Mastyugin V, Bonazzi A and Dunn MW. The angiogenic activity of 12(R)-hydroxyeicosatrienoic acid is mediated by vascular endothelial growth factor (VEGF). (2001) IOVS, Vol. 42, N 4, P. S90.

18.

Mastyugin V, Mosad S, Bonazzi A, Mezentsev A, Dunn MW and Laniado-Schwartzman M, Corneal epithelial VEGF and CYP4B1 expression in a rabbit model of closed eye contact lens wear. (2001) IOVS, Vol. 42, N 4, P. S480.

19.

Kutsenko AS, Mezentsev AV and Popov VO. NAD-dependent formate dehydrogenase of methylotrophic bacteria Pseudomonas sp. 101: 3D-symmetry of domains (1996) Proceeding of the conference “Autotrophic microorganisms” (Moscow), Summary Book.

20.

Mezentseva NV, Kuznetsov DA, Mezentsev AV, Kutsenko AS, and Popov VO. NAD-dependent formate dehydrogenase of methylotrophic bacteria Pseudomonas sp. 101: mapping of the active center with pyridoxal and its analogues (1996). Proceeding of the conference “Autotrophic microorganisms” (Moscow), Summary Book.

21.

Mezentsev AV, Ustinnikova TB, Tikhonova TV, Tishkov VI and Popov VO. NAD-dependent formate dehydrogenase of methylotrophic bacteria Pseudomonas sp. 101: Role of the essential arginine (Arg284) in the enzyme catalysis. (1996) Proceeding of the conference “Autotrophic microorganisms” (Moscow), Summary Book.

22.

Mezentsev AV, Ustinnikova TB, Tikhonova TV, Tishkov VI and Popov VO. NAD-dependent formate dehydrogenase of methylotrophic bacteria Pseudomonas sp. 101: Effect of pH on kinetic parameters and enzyme catalysis. (1996) Proceeding of the conference “Autotrophic microorganisms” (Moscow), Summary Book.

23.

Tishkov VI, Galkin AG, Mezentsev AV, Ustinnikova, TB, Popov VO and Shelukho DV. Biocatalysis-95. Molecular mechanism of NAD-dependent formate dehydrogenase: Site-directed mutagenesis of the enzyme active centre (1996) Proceedings of the International Conference. Suzdal, Russia, August 28-September 1, 1995.In: Appl. Biochem. Biotechnol. Vol. 61, N1-2, pp. 1-209.

24.

Mezentsev AV, Galkin AG, , Ustinnikova TB, Shelukho DV, Tishkov VI and Popov VO Catalytic mechanism and application of formate dehydrogenase: Site-directed mutagenesis of the essential arginine in the enzyme active centre. (1996) Proceedings of the International Conference. Suzdal, Russia, August 28-September 1, 1995.In: Appl. Biochem. Biotechnol. Vol. 61, N1-2, pp. 1-209.