Savillo, Isidro Antonio T. : Theoretical Biology Web Page : The Beginnings of Systems Biology.

`This web page chronicles the general activities of Isidro Antonio T. Savillo lest he forgets.`
Pls. visit the new web site at Isidro A. T. Savillo for recent news items.

04/21/2009~~Molecule of the Year Web Page of ISMCBBPR updated. Thanks to Matt Pagel of UC Davis!

Updated``04/20/2009-[03/06/2008~~Reminders: Authorship/Co-Authorship of foreign solicited scientific articles with Wetland scientists from: Vietnam: ongoing
Nepal: ongoing
Bangladesh: ongoing (Fundamental Determinants in Identifying Collaborative Management Approaches for Mangrove Ecosystems-- Bangladesh Case Study); for publication in JoWE.
India: submitted: To be published in SAFE's (India) Book in Biorights (ISBN Paris) hopefully to be made available by April 22, 2009 during World Earth's Day Celebration.
Taiwan:a

4/14 ``HAPPY NEW YEAR 2066 NEPAL!!`` The year 2009 is the year 2066 in the Nepali Bikram Sambat calendar. Also known as Baisakh 1 or Bisket Jatra. Thanks for this information Manoj Gautam! My Happy New Year Greetings to Manoj*, Gandhiv Kafle* and all the officers and members of the Wetland Friends of Nepal as well as the members of the advisory and editorial board and the rest of the staff of the JoWE.
*Country Designates of Nepal to Society of Wetland Scientist Asia Chapter.


4/12/2009``The Society of Wetland Scientists (SWS) Asia Chapter IOCCP- Program is staffed by outstanding wetland scientists and here are two of them:

4/12/2009``Society of Wetland Scientists Asia Chapter welcomes the famous wetland scientist from Cambodia, Mam Kosal to the IOCC Program of the SWS Asia Chapter. He has various and numerous activities and has been very active eversince in NGO projects. He is also the country designate (representative of Cambodia) to the SWS Asia Chapter. Search "Mam Kosal" in the internet...

4/12/2009~~ Society of Wetland Scientists Asia Chapter is proud to welcome Pisit Charnsnoh from Thailand, Goldman Prize Winner and an Associate Rolex Award Recipient as one of the Consultants and Collaborators of IOCC Program of SWS Asia Chapter. He is also a dugong expert and a Country Designate (representing Thailand )to the SWS Asia Chapter.

4/12/2009``Important Qoutes:
"Whoever, in middle age, attempts to realize the wishes and hopes of his early youth, invariably deceives himself. Each ten years of a man's life has its own fortunes, its own hopes, its own desires."- Johann Von Goethe
"Don't go through life, GROW through life."- Eric Butterworth

Life's Law

Updated: 04/09/09``[2/2009]`new address~~Inter/Intra Organizational Collaborative and Consultative Program (IOCCP-SWSASIA) of the SWS Asia Chapter: The backers-up for significant wetland project proposals and ongoing projects of any active SWS Asia Chapter Member.May we not concern ourselves first about the temperate wetlands of Kashmir and Jammu?

04/2009`Greetings during the 2008 Asian Wetland Convention and Workshop

~~3/26/2009-Reminder: Lichen Project -University of Southern Mindanao

~~Updated 3/25/2009~~[03/04/2009- Invited]~~ Member of the Editorial Board for The Journal of Wetlands Ecology.

3/25/2009``A Working Group Proposal is being sought for the Climate Change and Biodiversity Global Web Forum. Pls. read announcement here!

A Summary of the Participation (including photos) of Dr. Adel Budagher, SWS (Society of Wetland Scientists) Regional/Country Designate of the Middle East Region and Bahrain during the 2008 Asian Wetland Convention and Workshop in Taipei, Taiwan: Pls. click here.

Breather 1: ~~Mem'ries 6/2007 As Symposium (Asian Wetlands) Chair [Introducing the first speaker] during the 2007 Society of Wetland Scientists International Convention and Meeting at Sacramento Convention Center, Sacramento, California, U.S.A.``Photo Courtesy of Dr. Wei Ta Fang.
Presentation of Dr. Wei Ta Fang during the 2007 Society of Wetland Scientists International Convention and Annual Meeting in Sacramento, California.
Welcome Announcement of 2006 SWS Int'l Convention at Sacramento Sheraton, Sacramento, CA, U.S.A.



Breather 2:
~~Mem'ries 5/2008~Stranded look~ Photo while in Vancouver 1 (Pls. click square with arrows in photo for enlargement)
Photo while in Vancouver 2 enroute to Las Vegas and Washington D.C.

Breather 3:
~~Mem'ries /2006~~At Cairns, Queensland, Australia-- in a Restaurant tried the mega- hamburger

03/18/2009``ISCSPM (International Society for Collaborating Scientists in Personalized Medicine) welcomes Dr. Julio Licinio, President, International Society of Pharmacogenomics to the ~~ Scientific Organizational Designates Sector of ISCSPM.

03/15/2008a~~ Reminder: the 2010 Int. Conventions: Malaysia, Kuwait

03/15/2008b~~ Reminder: Board Meeting and Paper Presentation to the U.S.A. [Wisconsin] as scheduled.



2/25/2009~~Congratulations!~~ISMCBBPR's Molecule of the Year 2005: 4E10 and Dr. Dennis Burton's very outstanding profile. As an Internationally Released News Item: Press Release: The Scripps Research Institute as Recipient for the Molecule of the Year 2005 ; Science News.~Dr. Rosa Cardoso's honor as co- author.

2/24/2009~~ Congratulations to the Winner for the Molecule of the Year 2004 featured in the recipient's alma mater alumni magazine
As an Internationally Released News Item: Molecule of the Year 2004

2/23/2009~~ISMCBBPR as the authority for Molecule of the Year

2/20/2009~New Announcement (As proposed)!!The Forthcoming International Scientific Programme (ISP) of ISMCBBPR will be held in KUWAIT. The future Molecule of the Year will also be deliberated, voted and announced there during the ISP. Please regularly visit this site for updates!

2/17/2009~New Feature of ISMCBBPR: Job Postings- ISMCBBPR receives new job announcement from N.I.H., U.S.A.

Published Online -2/12/2009~As Keynote Speaker during the Archilife (Prestigious NGO in Taiwan) Research Communion at Grand Formosa Regent, Taipei, Taiwan
as part of the Scientific Program of the 2008 Asian Wetland Convention and Workshop, Taipei, Taiwan last October.

2/2009~A signatory to the Pacific Ocean Scientific Consensus Statement acknowledged by A.A., Planning Director, Center for Ocean Solutions, Stanford University, U.S.A., 11/03/2008

01/14/2009~~ ISMCBBPR's MoloftheYear2008 Web Page has a new look. Thanks to Matt D. Pagel of UC Davis.

01/10/2009~~Papers (from the Proceedings etc.) on Wetlands during the First SWS (Society of Wetland Scientists) Asia Chapter 2008 Asian Wetland Convention in Taipei, Taiwan : 1,2,3.

01/06/2009``ISCSPM (International Society for Collaborating Scientists in Personalized Medicine) welcomes Dr. Artemis P. Simopoulus, President, International Society of Nutrigenetics/Nutrigenomics to the ~~ Scientific Organizational Designates Sector of ISCSPM.

12/27/2008~~Molecule of the Year 2008 announced: 1,2,3

12/2008~~ISMCBBPR welcomes Matthew D. Pagel of UC Davis as the Membership Chair and Web Manager of ISMCBBPR!

Received 12/17/2008~~dated Nov. 21, 2008: Isidro A. T. Savillo -Selected as the Man of the Year 2008 (Philippines), American Biographical Institute, Inc.

12/16/2008~~Wetland, a treasure trove of new species!! Along the lengthy and winding Mekong River of Asia, more than 1000 new species were discovered.

11/2008~ Lichen conference in Asia is being planned. Pls. click here:a

12/11/2008~~ISMCBBPR Membership Update. ISMCBBPR welcomes new member from University of California Davis.

12/11/2008~ Climate Change and Biodiversity: A Global Web Forum will soon be linked in a monthly newsletter on Climate Change. This will help fill the positions for country representatives. This was decided by the conference manager for the International Convention in Climate Change.

12/11/2008~Calling SWS Asia Chapter Members!! A U.S. based Prestigious International Institution is looking for wetland authors and articles characteristics of or representing the wetlands of specific countries throughout Asia as well as the whole world for the project titled: Wetlands of the World that includes series of publications. If interested, pls. contact Prof. Isidro A. T. Savillo, Regional President, SWS Asia Chapter.

New Web Site of ISMCBBPR

*The Molecule of the Year 2008 will soon be announced through the President of ISMCBBPR, Prof. Isidro T. Savillo. It is famous as a promising, innovative and novel molecule with a worldwide press release and attention. Voting and Nomination for the Molecule of the Year 2008 will expire by November 30, 2008.*


11/2008~"The World is your School", said a former mentor and a Professor."Thank You"

Lake 2008

Listen to Taiwan National Radio News about the 2008 Society of Wetland Scientists Asia Chapter's First Asian Wetland Convention and Workshop

His Excellency Taiwan's President Congratulatory Message (Translated)

~~During the Society of Wetland Scientists (SWS) Asia Chapter's 2008 First Asian Wetland Convention and Workshop in Taiwan... Wonderful Days.... Great Natural Parks... and Exquisite 75 Wetlands... with warm reception from everyone...
At the TAIPEI BOARDWALK: Left to Right- Wei-Ta -Harvard University Alumnus and Representative of Taiwan to SWS (Society of Wetland Scientists) Asia Chapter, Chris - President, SWS Org, U.S.A.; Awardee, Pat - Past President, SWS Org , U.S.A. and Co- Signatory of the MoU for SWS and CPA, Ministry of Interior, Taiwan; Awardee and Isidro, Regional President, SWS Asia Chapter; Awardee. (All Photos Courtesy of Phuoc, Ph.D., Environmental Physics from Vietnam) Want to see Mamunul, Phuoc and Reiko? Pls. click here The Best memories ever! I hope that in the next convention/meeting, we can all be together - the SWS Asia Chapter Members ~ and that will bring a lot of splendid warm memories....
ASIAN WETLANDS: GLOBAL POSITION
Greater Mekong is recently identified as a major global hotspot for biodiversity, a treasure?, One of Global Positions of Asian Wetlands (see Keynote Speech below).

L-R: The Honorables- Yeong-Tyi, Isidro (as Keynote Speaker), Judy and Ching-Hua at the Grand Formosa Regent, Taipei.

Thanks to Minister Liao of the Ministry of Interior, Taiwan.



12/06/2008~Wetlands are a Top Priority for Climate Change in Asia. Excess heat and rain target primarily the wetlands. In effect, there are a lot of interacting webs that these affected wetlands are likewise affecting. ~ Statement by Prof. Isidro A. T. Savillo

11/2008~Currently organizing (as one of the major organizers) the proposed conference on asian wetlands having an international perspective with emphasis to the participation of third world wetland scientists.{[EXCLUSIVE FOR SOCIETY OF WETLAND SCIENTISTS ASIA CHAPTER] As what I talked about during my paper presentation ( Revivifying the SAVI Pouch: An Advocacy) at the SWS (Society of Wetland Scientists) Asia Chapter 2008 First Asian Wetlands Convention and Workshop in Taipei, Taiwan, One of the goals of this proposed conference will be presentations of Case Studies by Wetland Scientists from (third world) countries worldwide on the effects of climate change to wetlands basing on the Taipei Declaration on Asian Wetlands (Please see below for the link of this Declaration). The Case Studies will be discussed and deliberated by experts and solutions will be offered/attempted. The final edited outcome will be provided to all attending countries: to governments, NGOs and citizenry.}11/2008~ Current co-organizer: Director of Research of a Prestigious International Organization from Australia with worldwide branches.

11/07/2008~~
News Item (Awardees of the SWS Asia Chapter's 2008 Asian Wetland Convention and Workshop etc.) from the WFN (Wetland Friends of Nepal)

Achievements in , a successful bilingual conference, the SWS Asia Chapter's First 2008 Asian Wetland Convention and Workshop~Oct. 23- 26, 2008:

Awardee:10/24/2008~~Certificate of Taiwan's Wetland Conservation Honorable Advisor granted by the Minister of the Ministry of Interior, Republic of China. A part of the citation reads.."Prof. Savillo leads the international management of wetlands with the beauty of innovative craftsmanship and concept as well as helps Taiwan's wetlands flourish."

Editor of two proceedings (General and Proceedings II) and also wrote the Preface for the Proceedings II of the First 2008 Asian Wetland Convention and Workshop. Proceedings cited as:

Pang, Y.-H, W.-T. Fang and I. T. Savillo (eds) 2008 Asian Wetlands: Global Position. English Proceedings (Proceedings II) of the First SWS Asia Chapter's Asian Wetland Convention and Workshop. 23-26 October. Construction and Planning Agency (CPA), Taipei,Taiwan(ROC).

Pang, Y.-H, W.-T. Fang and I. T. Savillo (eds) 2008 Asian Wetlands: Global Position. General Proceedings of the First SWS Asia Chapter's Asian Wetland Convention and Workshop.
23-26 October. Construction and Planning Agency (CPA), Taipei,Taiwan(ROC).

Two Keynote speeches at the NTUHICC and at the Formosa Regent (Pls. see General Proceedings)

Co - authorship: Chou, Jui-Yu, I. T. Savillo and W. T Fang. 2008. A Logistic Regression Approach to Explore Pondscape Changes in Taoyuan, Taiwan from 1926- 1960. In the proceedings authored by Pang, Y.-H, W.-T. Fang and I. T. Savillo (eds) 2008 Asian Wetlands: Global Position. Proceedings of the First Asian SWS Asia Chapter's Wetland Convention and Workshop. 23-26 October.Construction and Planning Agency (CPA), Taipei, Taiwan (ROC)

Paper presentation: Revivifying the Savi Pouch, An Advocacy

Participated in panel discussions including the drafting of the Taipei Declaration on Asian Wetlands and on the MoU.

Witness Signatory for the MoU.


10/21/08~~Off For Taiwan ~~ Matters will be entertained first week of November, 2008

WFN-08/14/2008~~ Network Partners- NEPAL

08/10/2008`~~Appropriate Definition of Personalized Medicine and click on ISCSPM, the International Society for Collaborating Scientists in Personalized Medicine.

07/20/2008~Reminder and Note: Certification in the field of Human Dynamics, Human Complex Behaviors in Organizational Development, etc. will soon be in Asia... Proposed Organizers: Isidro T. Savillo and someone from Hong kong SAR, and the Great Fellows and International Consultants from the Main Office in the U.S.A.

Received July 11, 2008~~2008 MAN OF THE YEAR IN SCIENCE- American Biographical Institute (ABI) dated Feb. 2008

updated 6/11/2008~Schedule at a Glance of the SWS Asia Chapter's First 2008 Asian Wetland Convention and Workshop

Updated 06/06/2008: 2008 Asian Wetland Convention and Workshop of SWS Asia Chapter

Official Trips for 2008*
1.May 2008~Off to Washington D.C., U.S.A.
~Board Meetings, Paper Presentor, etc. at the 2008 SWS International Conference and Annual Meeting
Venue: Marriott Wardman Park Hotel, Washington, D.C., USA

2. Oct. 21, 2008~~Taipei, Taiwan~Keynote speaker, Round Table Discussions with Distinguished High Ranking Taiwanese Government Officials and Prominent Guests, Meetings, MoU matters, etc.
Preliminary Program in TAIWAN 2008.

*I may not be able to answer your emails as soon as possible during the trip schedule. May be very busy to consider other matters. Thanks.

Climate Change and Biodiversity: A Global Web Forum

How does it feel for the Molecule of the Year 2008 be judged by a group of famous world scholars in molecular and cell biology and biotechnology? Of course, it will be a very exciting event! Keep our fingers crossed. And find out later the scientific thrill behind all of this!

Invited to attend the 2008 World Forum of the American Biographical Institute, Inc. (ABI), a private forum not open for public and attendance is limited to outstanding individuals whose background achievements have been known and admired by ABI on August 23-26, 2008 at Oxford University [St. Catherine?s College, Oxford, England]. This will engender unique opportunities for international men and women of all ages and professions to convene and be a part of stimulating symposiums, cultural exchange and discovery. A Pre-Forum Cultural Programme will be held prior to the event, August 23 ? 26, 2008, including a special tour of Buckingham Palace.

Think Tank Honorary Position- South Asian Forum for Environment (Indian Chapter)

Drawing the Line Between Theoretical and Basic Biology

YOU ARE INVITED!!
 All Wetland scientists and enthusiasts are invited to attend and participate in the SWS (Society of Wetland Scientists) Asia Chapter's 2008 Asian Wetland Convention and Workshop this coming Oct., 2008 in Taiwan.


Received Feb. 06, 2008- Dated Nov. 2007~ Invited to become a member of and seat on the Distinguished RESEARCH BOARD OF ADVISORS of the American Biographical Institute, Inc.

Molecule of the Year 2007 is the pkd2l1

January 03, 2008
--Prof. Isidro A. T. Savillo*
*Granted a Doctoris Honoris Causa by a University in the U.S.A.

For the Year 2007
--Prof. Isidro A. T. Savillo*
*2007/2008 Great Minds of the 21st Century, American Biographical Institute, Inc. (ABI)
*Man of the Year 2007, American Biographical Institute, Inc. (ABI)
*Gold Medal for the Philippines 2007, American Biographical Institute, Inc. (ABI)

International Society for Collaborating Scientists in Personalized Medicine is now at Personalized Medicine.com : The Personalized Medicine Portal

Proposed SWS Section : Wetland Molecular Ecology/Biology
Organizer of ISMCBBPR: Prof. Isidro A. T. Savillo

10/2007~ Please visit : Directory of Cell Biology Organizations

8/03/2007~~Prof. Isidro A. T. Savillo is hereby nominated by the American Biographical Institute
 to receive the 2007 Gold Medal for the Philippines.  A part of the citation reads:   "Through this research, your name has been nominated as one who personifies passion, courage, commitment, success, excellence, virtue and spirit- the exact qualities necessary to receive a Gold Medal for your country." For all other awards by the American Biographical Institute bestowed upon Prof. Isidro T. Savillo, please scroll below. Thanks.

International Society for Collaborating Scientists in Personalized Medicine (ISCSPM), conceptualized in 2006 by Prof. Isidro A. T. Savillo of ISMCBBPR and Dr. Steven Murphy of Helixhealth.  Dr. Steven Murphy is well known as the FOUNDER of PERSONALIZED MEDICINE PRACTISE
and currently doing research at Yale University.

2008 Asian Wetland Convention and Workshop sponsored by SWS Asia Chapter

Regional President, SWS Asia Chapter - Prof. Isidro A. T. Savillo

For Prof. I. Savillo's international nominations and awards, pls. scroll below. Great Thanks for his official nominators who ever they are!!

Approval of FULSPEC (Fulbright Senior Specialist Program) Project 2217 proposed by Prof. Isidro A. T. Savillo- 6/2006

Theoretical Biology: Prof. Isidro T. Savillo
Theoretical Biology - Prof. Isidro Savillo
This web page introduces basic concepts in molecular and cell biology, modifies or improves or corrects various theories or principles or beliefs known to be popular in biology

The Official Nomination of Prof. Isidro Antonio T. Savillo is hereby endorsed by the Governing Board of Editors of the American Biographical Institute, Inc. (ABI) for inclusion in the 2007/2008 Great Minds of the 21st Century. As an Awardee, he is given the privilege to be an Official Nominator for ABI Reference Publications.
22/June/2007  Prof. Isidro T. Savillo is nominated for the prestigious title MAN OF THE YEAR 2007 by the Governing Board of Editors of the American Biographical Institute (ABI) through the recommendation of the Institute's International Board of Research. Upon acceptance it will entitle him the awards.
08/07/2007~The two above mentioned nominations - Biographical Inclusion to the 2007/2008 Volume of the Great Minds of the 21st Century and the entitlement of the Man of the Year 2007 are both awarded to Prof. Isidro A. T. Savillo after thorough analyses of his biographical information (with a global impact) by the Governing Board of Editors of the American Biographical Institute, Inc.
Visit abi.
Visit my Scientific Links:
Something strange on 11/26/2008: This web page had 97 hits. In case of unlawful use of this web page and owner's name without prior permission from the owner, pls send an email to :
theoretical_biologist@yahoo.com Thanks a lot for your cooperation.

Locations of visitors to this page

Calling Scientists' Voters for the Molecule of the Year 2009

As a Theoretical Biologist in the Theoretical Biology Directory~ (2008)

International Society for Collaborating Scientists in Personalized Medicine (ISCSPM) in the Genetics Directory

Philippine Myxomycetes and other Slime Molds in the Myxomycota Directory

Taxonomy of Philippine Lichens in the Lichens Directory

International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches (ISMCBBPR)in the Cell Biology Organizations Directory

Announcement!! Wanted: Publications...

The Overpowering Influence of the Environment to Gene Expression
[Please Note that the Recommendations for this 2002 article is on Systems Biology]

The Role of the Environment: A Twist in Genetic Expression

To access both articles , please click on BiologyBrowser:Genetics

4/3/2008~New Additions:
Molecule of the Year 2007
Drawing the line between Theoretical and Basic Biology


Life's Law by Prof. Isidro A. T. Savillo `04/09/2009 "Our Genes develop us to our breath, Likewise, Our Genes decipher us to our death."

02/07/2009~ Human Exogeneous Genetics- I brought this out as an important new specialized field of Human Genetics . One example is Microbial Gene Insertion in Human Chromosomes and their role in Human Pathogenesis.

12/06/08~ Just like any type of human behavior, the expectations of sexual behavioral phenotype can be twisted by the environment and are not wholly genetically based.

A Very interesting book: The Blu Zones- Lessons for Living Longer from the People who've lived the Longest by Dan Buettner

12/24/2008~ I questioned the existence of "instinct" in my former article below. (Wikipedia states that it is directly hard wired from the brain. Seem autonomic- like). And it's good to come back to it. Anything that an organism do is environmentally influenced like in animal courtship, in breathing, in standing up for the ist time as observed in complex lower form of animals, etc. It's a cascade mechanism of signals initiated by birth- just like the bloating of the lungs once the fetus is out of her mom's placenta that will initiate lung- breathing reflexes. The biophysical influence of the environment here is working. So much more in lower forms of animals way of standing up....the muti- interactions of organ systems such as the circulatory system, the extension mechanisms of the limbs and the bodies ripe need* for oxygen will drive the animal to stand...and the smell of milk will lead to his sucking needs or her mom's intimate* "signals". Environmental influence can either be intrinsic (within the organism) or extrinsic (outside of the organism) but the best answer is both. Well human babies are the lowest graded when it comes to environmentally influenced reactions independent of parents compared to complex lower forms of animals. Human babies are slaves to philosophies of their caretakers until they grow to be what they are as influenced in toto (by the enviroment and their genes). They just can't do things on their own. Not only they inherit the culture of their caretakers but also their caretakers' economic status because of too much dependence since birth.

* When one had a very stuffy nose and at bed asleep will he not unexpectedly crave to get up for air; a mother hen could no longer recognize the chick that she hatched so she pecked on the poor being.. so the chick will make the human caretaker as imprint "mom" whenever the caretaker feed the chick or wherever the caretaker goes the chick follows.

12/27/2008`` Is there a synchrony between the formal classic educational system (up to graduate programs) with that of the growth and development of the human being. Or is it too long? leading to excessive dependency and exorbitant expenses?

09/2008~Genes for Visual Likiness and Dislikeness (Disliking) have not been deciphered and are in present form complicated but not as stimulating and simply presented like the pheromones. We need for more specific findings on the Genes for Visual Likeness and Dislikeness(e.g. behavior in sexual phenotypes) to know why organisms including humans visually behave that way.

Philosophy of Biology : A New Model: The Components of Life must be used or experienced specifically on a moderate level in order to attain genuine satisfaction and real happiness. Too little or too much of anything is unhealthy biologically. ~I. Savillo 05/2008

Family Counseling in the Post Genomic Era- Families will now include genetic elaborations as part of their family counseling and guidance especially with their young children. Commonly, in some parts of tropical Asia, it is known that the "undesirable genes" (pls. see below regarding definition) start to appear more or less during the age of 45 thus the monies earned will mostly go to the buying of maintenance medicines as well as physician consultations, hospitalizations etc. It is a must that the young children and couples would start physiological and economic aggressiveness as early as possible so as to realize wholesome satisfaction and benefits, respectively of their lives prior to the onset of their genetic diseases.~I. A. Savillo 8/06/2007


Epigenetic switches: When the environment influenced the switching on and off of genes, it becomes a part of an ancestral lineage while being spooled into as environmental memory. Don't underestimate the role of environment in genetic influence. This is another clear proof. ~I. Savillo,7/26/2006

*Mendelian Inheritance is Phenotypic Science. Sometimes the phenotypic "key" awkwardly fits the genotypic "lock". Otherwise there will be no such thing as evolution. Moreover there are some genetic mechanisms which follow the Mendelian Laws but where are the genes?Isidro Savillo* 3/22/2006 (modified 9/09/2007)

Perpetuation of the Species is more important than Standard Reproduction
The process of reproduction does not always follows the gender sensitivity rule. As observed in various levels of organisms, gametes are also shed or released in unconscious situations but may have the goal towards successful fertilization. Irregardless of what type of reproductive processes, evolution has patterned life to continue urgently the perpetuation of the species. Isidro Savillo* 3/12/2006


The BRAIN IS COMPROMISING: THE BRAIN THINKS what's THE BEST FOR THE THINKER*
  *This is applicable to human behavior and planning to work on this new statement of mine. (11/20/2004)

EGO GENE: UNIVERSAL FOR ALL SPECIES
Regardless of any status in whatever categories the EGO GENE is expressed on particular situations and are visually comprehensible in higher organisms [in progress]11/2004.

Environmental Patterning in the Expression of Genes (in progress)
  The cascade mechanisms involved in the environmental patterning of the structural, behavioral and physiological phenotypes are exhaustively described. This represents an overview or outline of the three ways of phenotypic production in the individual organism.

On Relationships and Babies (in progress)
  These two exogenous factors (relationships and babies) are comparatively analyzed, which of them, has a substantial role as universal gene effector. Gene effectors could either be activators or depressors of behavior. As a universal gene effector, it may have a great effect to the overall composition of the individual organism and may bring drastic results.

Late Expression of Undesirable Phenotypes: Life's Inescapable Havoc (in progress)

"The full blown expression of undesirable phenotypes in adults has been served by physiological hints and signals earlier in life which most have dissuaded or ignored. But these are the basis of future bodily catastrophes. To own a genomic profile with a layman's explanation may help protect the individual with proper physiological and environmental treatments thus lessen suffering and may extend survivality." by Isidro T. Savillo, 8/28/2005

IN DEFENSE OF MOLECULAR SOCIOLOGY and PHILOSOPHY
  Philosophical and Sociological Studies without the genetic, molecular and cellular bearings or support are never scientific. They are just guesses or hypotheses, products of sensual observations and surveys, dependent on the ficklemindedness of the respondents and shamefully, such researches are considered for the highest achievement. They are phenotypes, phenotypes, phenotypes.... without the genes, cells and molecules with their respective environmental interactions, importantly, responsible for the production of such phenotypes.
5/2007 

   ~I. Savillo

**Beyond the Genome: All Men are created equal. This "biblical(?)" statement is beginning to take root with the continuous process in the meticulous analyses of genomic profiles of the human individuals. A certain individual has "billions of bad genes" and these are continuously growing. Their expressions may be direct, environmentally induced, semi- lethal, or whatever (as long as they are expressed), niched in various biochemical pathways or solitary. So, too the good genes and these are also continuously growing. Another individual has "billions and a one bad genes" and these are continuously growing so too with his good genes. At the onset of late adulthood, there will be "trillions of bad genes" and less good genes eventually leading to mortality. At a certain point in time in a specific dimension, there is an equality of the expressions of these bad and good genes but the process of adding and subtracting would make ones list longer than the other and later a vice versa but as this is of similar ruling to all humans, then there is still a basis for equality. With the continuous growth of molecular and cell biology, no bad or good gene be missed for correction or improvement. Appropriate environmental and physiological treatments are beginning to be felt with the advent of personalized medicine. THEN, why discriminate oneself? Why loose confidence? When every human is a bunch of more bad than good genes (that's why it leads to death). An astute geneticist can identify dozens of bad genes by just one look at the individual. A genomic profile will give one a reason to make as many personal insults to anyone including his next generations. Then, why are these people behaving as if they are superior than the others. I find it useless and meaningless. *Prof. Isidro T. Savillo

**Posted at the Scientists Solution Forum

Update 04/15/2009`` Though I made a pioneering statement (way back 2001) on the Impermanence of Sexual Phenotypes that includes behavior, this has nothing to do with the legalization of same sex marriages that are presently sprouting or I condone them or other derivative explanations. But I think what the lawyers are proposing is something to what they have observed or probably have studied extensively. As an example, human sexual reproduction among siblings will create a very big possibiliy of abnormalities in progenies. Because this has happened and were observed to happen , then a derivative law about it was established (Is there such a thing?).``Prof. Savillo's other article that could shed to the impermanence of sexual phenotypes is located here.~~ Announcement: ISIDRO A. T. SAVILLO is preparing a REVIEW on the Molecular Biology of Sexual Genotypes and Phenotypes covering all higher organisms including fishes as one aspect. Scientific articles with GENE- ENVIRONMENT context are also essentially welcomed. One of the subjects in the categories mentioned above that Prof. Isidro A. T. Savillo is going to work upon is entitled, "THE IMPERMANENCE OF SEXUAL PHENOTYPES"and this topic is exclusively reserved for him.  BIOLOGICAL scientists worldwide who have published peer reviewed papers on these areas must come in contact with Prof. Isidro A. T. SAVILLO using the email address of this web page. The manuscript will soon be published in a prestigious UK journal with the coordination of a prestigious editor in Molecular Biology.[Oct. 08, 2004]


"Protandric or Protogynic hermaphroditism in nature, is strange and unique: a couple of slipper shells transform themselves into females once the population lacks them, likewise, in Family Serranidae, female fishes become males at certain years of existence. A parallel situation towards the "hermaphroditic" aspect is observed in some humans: a change in sexual phenotypes towards adulthood, unexpected because of the "normalcy" shown during the toddler stage or previous to that. In certain circumstances, changes in sexual phenotypes may occur since birth or even earlier. Will the fruitless gene leads the answer?" by Isidro A. T. Savillo, 8/29/2005

"Can plants change sexual phenotypes? According to a native source, repetitive cutting of a male Carica papaya will convert the plant into a female. Pulpits can change sexual phenotypes depending on the stored substrates of the previous season as well as that of the cucurbits. The latter would do so depending on the application of a suitable plant growth regulator (Metcalf, T. 2005 , Personal Communcation). Particular literatures on Silene noctiflora, Ceratopteris, Buchloe dactyloides and Actinidia deliciosa have shown sexual phenotype changes to a particular extent (Meyerowitz, E. 2005 Personal Communication).~Isidro A. T. Savillo 8/29/2005.

Kudos to this definition of Systems Biology : *"Systems Biology is not the biology of systems. Instead it is the region between the individual components and the system, which is why it's new. It's those new properties that arise when you go from the molecule to the system. It's different from physiology or holism, which study the entire system. It's different from reductionist things like molecular biology which only studies the molecules. It's the in between (Pls. see below the # sign)."
~Hans V. Westerhoff, Ph.D.
Department of Molecular Cell Physiology
BioCentrum Amsterdam
*Cited in the Institute of Systems Biology Web Site


ON the "Genetic Spread" of GMOs in the Environment

What is Terminator Technology? One of the goals is to permit GM plant use without 'gene escape' to wild relatives or landraces. As stated by the authors, Zac Hanley and Kieran Elborough, "If GURT (Genetic Use Restriction Technologies) research had not been inhibited, would the transgenes in today's elite GE maize be constrained by guaranteed pollen sterility, or be automatically deleted from the genome at the initiation of the reproductive growth phase? Perhaps not given the timeframe available, but if GURTs are finally recognized as valuable tools for biotechnology industry when used in the appropriate context, they should provide safeguards against similar occurences."[From: ISB] In 1998, Isidro Savillo has quite a similar concern when he wrote The Science of Genetic Control."
[Courtesy of Indiana University -Archive for Biology {IUBio Archive for Biology}]


An Introduction to SYSTEMS BIOLOGY


 [in this essay, the weight or the emphasis is on Systems Biology]

With the indispensable presence of molecular and cell biology, our ideas are focused to the minute analyses of the cellular and molecular mechanisms which are the pillars of structural, behavioral and physiological phenotypes that our lives are seated upon.

   In this respect, I would like to see more concrete explanations of the phenomenal existence of the GENE. Can the Gene be expressed without being influenced by its environment? How "constitutive" are the constitutive genes? In my paper, "The Overpowering Influence of the Environment to Gene Expression," I introduced the earth as a "biological incubator" for all living organisms. The abiotic components of the environment are essential for its "incubatory" mechanisms for our genes/cells to function though the optimal range is broad for most. I introduced two types of environment: the exogenous and endogenous environments. The exogenous environment may be an abiotic or a biotic product influencing the individual. Thus, it may come from the chemicals, heat, etc. or someone else's genes. The endogenous environment comprise of physical factors (e.g. temperature, hydration, pressure, etc) which may be independent of the genes but if not for the exogenous environment, they could not have been a part of the cellular metabolism. Most of the endogenous environments are products of the genes of the individual and the physical factors which are produced as a result of it or by their various biochemical interactions.
Thus, if we have to root out the real cause of gene expression, we have to think of the abiotic exogenous environments we are in and how it managed to  allow both the biotic and abiotic exogenous environmental factors to further influence the endogenous environment for the expression of genes.

  To further cut this into slices of special problems, I posed a number of essential queries which target the specificity of the genes. Are genes strong enough to defy environmental influences? Do we have to adjust to the needs of our genes? Our genes respond to any environmental influences and this would eventually lead to the death or survival of the organism. Considering that our genes have the imperfect components, adjusting to the needs of our genes may help but putting up a perfect environmental condition is impossible. The interactions of various environmental factors are affecting various biochemical pathways or evolving into one/many new pathways and specifically adjusting the numerous exogenous and endogenous environments for these is difficult to attain. Genes could specifically produce phenotypic characteristics but in the presence of certain types of endogenous and exogenous environments, there may be some forms of confusion leading to erroneous genetic products. In developmental biology, there are many cellular and molecular interactions of non indigenous substances to the cells of the embryo. Thus, the embryo is floating to new mixes of substances which are not the products of his own genetic materials. This could   contribute to the modification of his phenotype. When it comes to sexes, I posed a question, Is there permanency in sexual phenotypes? How about the clones and the monozygotic twins? It's time to stop saying that "they are phenotypically similar because they are genotypically the same." How about "instincts?" Are there really instincts or are they slaves to environmental pulses or signals? In terms of behavioral analyses, what is missing?# The molecular bridge from the exogenous environment to the senses (via the endogenous environment) is one of those cellular and molecular mechanisms that could eventually make out a complete picture of behavior which had been usually gathered through observations and surveys. I have to introduce a new field of "Molecular Sociology & Philosophy "to satisfy this option of in toto comprehensive analyses. Absolutely, inherited genes are difficult to change. Can you change your height or your looks? Thus, we live with it. If we have to change a certain part of our phenotype, we call that as "cosmetic genetics." The problems of maintenance come in. It was not a part of the familiarization processes of the embryonic cells and new adjustments could rarely be recognized by the adult cells. Because one has a defective gene, it doesn't mean that the environment has nothing to do with it. But the environment is superior in allowing the gametes to fertilize and produce an individual with a defective gene. Defective genes are important to evolution. The wobbling of the nitrogenous bases will allow the most adjusted ( depending on the appropriate protein structures called upon by the new environment) species to survive and reproduce. What about culture? Culture controls phenotype evolution or expression and may not be favorable for some. These are just a few of the major constructions I would like to work into as Part I of my research studies. I think there is a need to change old knowledge for new or modify them to some extent. Once a theory is firmly established, it will be subjected to molecular (mathematical/biological) modelling. The pioneering knowledge taken from these analyses are important for the betterment in the understanding of ourselves in the molecular and cellular levels. 

  --Prof. Isidro A. T. Savillo*
*2007/2008 Great Minds of the 21st Century, American Biographical Institute, Inc. (ABI)
*Man of the Year 2007, American Biographical Institute, Inc. (ABI)
*Gold Medal for the Philippines 2007, American Biographical Institute, Inc. (ABI)


Prof. Isidro A. T. Savillo*

*Member MTBIO - Modelling and Theory in BioSciences based in the Federal Republic of Germany.

Email Address:
theoretical_biologist@yahoo.com

Isidro Antonio T. Savillo's exposure in molecular and cell biology started as a graduate student at the University of the Philippines, Diliman, Q.C. [ During that time he received a complimentary copy of the first edition of "Molecular Cloning: A Laboratory Manual," from the Cold Spring Harbor Laboratory, U.S.A.]  This was further enhanced by taking academic units, undergoing trainings and research participations at the California State University  (Detection of the Serum Retinol- Binding Like Protein in Octopus bimaculoides)  and the University of Southern California School of Medicine Molecular Pathology Laboratories (Molecular Analysis of A Novel Virus Isolated From A Patient With a Chronic Fatigue Syndrome). He has considerable experience working in standard Clinical Microbiology Laboratories both at the University of Southern California School of Medicine Clinical Laboratories and in Private Laboratories. He is interested in Emerging Diseases and was once a Resource Person in this category at the Public Health Forum of the University of the Philippines in the Visayas' Division of Biological Sciences. He is a corresponding member of the International Society for Infectious Diseases based at Harvard University. He is currently working a research project in severe malaria in potential collaboration with a U.S. scientist and group specializing in immunology and genetics. He participated in researches funded by the US-AID (United States Agency for International Development), NIH-MBRS (National Institute of Health- Minority Biomedical Research Support, U.S.A.) and NSF (National Science Foundation, U.S.A.). His latest attendance to international conferences were funded by the AusAID (2006),SWS Org. (2007) and SWS Org (2008).  Prof. I. Savillo founded, organized and is currently the President of the International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches, Inc. (ISMCBBPR). The society is recognized internationally especially their annual nomination, deliberation and announcement for the Molecule(s) of the Year ( 2004, 2005, 2006, 2007). He is the organizer of the soon- be- active International Society for Collaborating Scientists in Personalized Medicine (ISCSPM). He espouses basic researches in molecular and cell biology and one time, established the Molecular Analysis of Symbiosis (MAS) Homepage (Web Page Developed by Vera Besse from Austria and MAS Featured in the first issue of the International Symbiosis Society Newsletter). In addition to molecular and cell biology, he is also active in microbiology researches involving the least studied microoganims. He was a DAAD (Deutscher Akademischer Austauschdienst) research scholar, at the world famous Botanic Garden and Botanical Museum (BGBM), Freie Universitat Berlin in 2001 by studying the tropical lichens at the B herbarium. He was cited in the 2003 Key to the Lichen Genera of Bogor, Cibodas and Singapore. His lichen articles can be accessed at Thomson Scientific's Biologybrowser (Geography--Asia) Database. On the last week of March 2005 and thereafter, he serves as the External Supervisor in the Lichen Project of Shirley Michelle Dulnuan studying in   Bishop's University, Quebec, Canada.   His abstract entitled "Analyses of Air Pollution in Cities Using Predominant Pollution Tolerant Lichen Species" has been recently accepted for presentation at the 11th International Conference of the Pacific Basin Consortium: Threats to Human Health and Sustainability in the Pacific Basin: Environmental Pollutants and Climate Change at East West Center, Honolulu, Hawaii.  Since September 2003, he is a Research Associate and an International Research Collaborator in a Planetary Biodiversity Inventory-National Science Foundation (NSF, U.S.A.) funded 5 year-project entitled: The Global Biodiversity of Eumycetozoans, a University of Arkansas, U.S.A. based research. He is cited as a Taxonomist in a Japanese GTI Web Page. He also Co- Chairs with Dr. Kwi Gon Kim of Korea,  the establishment of the SWS (Society of Wetland Scientists) Asia Chapter. Watch out for the 2008 SWS Asia Chapter Asian Wetland Convention and Workshop at National Taiwan University Hospital International Convention Center! He coordinates with members (SWS U.S.A. of Asian Addresses) and members-to-be in all of Asia.  Last June 10, 2005, the Society of Wetland Scientists Asia Chapter has been approved and ratified by the SWS Board and the General Membership, respectively, with Prof. I. Savillo as the Regional President of the SWS Asia Chapter and a Member of the Board of Directors (since mid 2005) of the SWS.  He is also recently appointed by Dr. Barbara L. Bedford, Cornell University, Current President (2005-2006), SWS, as One of the Seven Members of the Membership Committee of the Society of Wetland Scientists Org, U.S.A. with Dr. Beth Middleton, USGS, SWS Secretary General as Chair. His participation to the Catchments to Coast International Conference and attendance to the 27th SWS Annual Board Meeting in Cairns Convention Centre, Cairns, Queensland, Australia was funded by the Australian Government. Last June 10- 15, 2007 , he attended the Society of Wetland Scientists International Convention and the SWS Annual Board Meeting at the Sacramento Convention Center and the Sheraton Grand Sacramento Hotel, California, U.S.A. In the program, He chaired the ist SWS Asia Chapter Asian Wetland Symposium and presented a paper. His travel was funded by the SWS Org. Thanks to Dr. Mary Kentula, EPA, Current President, SWS (2006-2007) for all her efforts in helping internationalize SWS Org. Last May 24- 30, 2008, he attended the Society of Wetland Scientists International Convention and Annual Board Meeting at the Marriott Wardman Park Hotel, Washington, D.C., U.S.A. He presented a paper entitled: Ecological and Economic Status of a Reforested Mangrove: Basis for Sustainable Development besides attending the Annual Board Meeting. His travel was funded by SWS Org. Thanks to Dr. Patrick Megonigal, President of SWS 2007-2008 and it was also Dr. Megonigal's time that the Memorandum of Understanding for the 2008 Asian Wetland Convention and Workshop slated in Taipei, Taiwan this coming October, 2008 was undertaken. The major sponsor for the First SWS Asia Chapter's 2008 Asian Wetland Convention and Workshop is Director General Charles Chin- Rong Lin, CPA, Ministry of Interior, Taiwan. An unexpected stay at Marriott Vancouver at Vancouver, Canada was an extra treat by the airline. Dr. Christopher Craft , Indiana University, U.S.A., the new President(2008-2009) of Society of Wetland Scientists, Inc. has appointed Prof. Savillo as a member of the Membership Committee of the SWS for the period 2008- 2011. Prof. Savillo is also interested in the identification of bryophytes which he encounters in his research areas and is presently collaborating this endeavor with a staff of the University of Malaya Herbarium. The International Symbiosis Society featured him in late 2004 in their People's Web Page regarding his publications on Lichens. Usually his articles can be found in the database of the BiologyBrowser. His taxonomic expertise also include Fishes of the Philippines and was once a Resource Person in this category in a Fish Examiners' Seminar-Workshop sponsored by the Bureau of Fisheries and Aquatic Resources, Region VI. Just recently, he become one of the members of the Regional Wildlife Management Committee, PAWB, DENR whose main goal is to help conserve the country's natural resources and preserve wildlife. He is currently writing new theories on sexual genotypes- phenotypes and on gene- environment interactions as invited by a molecular biology journal(based in UK) with a competent editor from a University in Italy. He has also interest in Bioindicator Researches involving Lichens and Mosses and has presented a number of papers/ workshop on these areas. In the field of arts, he was a former student of the UCLA Professional Screenwriting Program and was able to produce one manuscript, a novel, entitled, "Yelwa-Yauri", copyright registered at the Library of Congress, Washington, D.C., U.S.A. His novels or scripts are usually based in the different places (e.g. Yelwa- Yauri, Nigeria) of the world which he visited since 18 when he "circumnavigated" the world for the first time. He also had been to the major provinces of the Philippines like Zamboanga, Davao, Leyte, etc. as part of his teaching carreer or for vacation. He is a member of various biological societies here and abroad.
~updated 8/27/2007

Fields of interest: Theoretical biology-Organizational development and leadership in Global levels-Biological Sciences and Wetlands-Microbiology (Clinical and Non- Clinical)-Molecular and Cell Biology-Molecular Pathology-Personalized Medicine and Systems Biology-Creative Writing (Screenwriter and Novelist)

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