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Education and Professional Experience:
1992: B.S.-M.S., Biology (Molecular Biology), University of Oviedo (Spain).
1997: Ph.D., Biology (Molecular Biology/Microbiology), University of Oviedo (Spain). Supervisors: Jose A. Salas and Gloria Blanco.
1997-2000: Postdoctoral, Department of Chemistry, University of California, Davis (United States). Supervisor: Ben Shen.
2000-2006: Research Scientist, Institute of Oncology, University of Oviedo (Spain).
2006-2007: Senior Scientist, EntreChem SL, Oviedo (Spain).
Main Expertise:
Genetic engineering of microorganisms for the development of new antibiotics and antitumor drugs.
Generally, the microorganisms used for this purpose are bacteria of the Actinomycete group (genus Streptomyces and related) that produce compounds possessing antimicrobial and antitumor activities. Actinomycetes, and particularly streptomycetes, are the most versatile and commercially important producers of natural bioactive compounds (antibiotics, antiparasitic, antitumor, immunosuppressive, etc.). Recently, the advances made in understanding the genetics of microbial metabolism have opened excellent possibilities for the generation of new drug candidates by genetic engineering of microorganisms.
KEYWORDS: Antibiotics, antitumor, natural products, secondary metabolism, genetic engineering, metabolic engineering, combinatorial biosynthesis, drug discovery and development, bacterial genetics, actinomycetes, Streptomyces.
Selected Publications:
Sanchez C, Mendez C, Salas JA. 2006. Indolocarbazole natural products: occurrence, biosynthesis, and biological activity. Nat. Prod. Rep. 23:1007-1045.
Sanchez C, Brana AF, Mendez C, Salas JA. 2006. Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis. Chembiochem 7:1231-1240.
Sanchez C, Zhu L, Brana AF, Salas AP, Rohr J, Mendez C, Salas JA. 2005. Combinatorial biosynthesis of antitumor indolocarbazole compounds.
Sanchez C, Butovich IA, Brana AF, Rohr J, Mendez C, Salas JA. 2002. The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem. Biol. 9:519-531.
Sanchez C, Du L, Edwards DJ, Toney MD, Shen B. 2001. Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chem. Biol. 8:725-738.
Du L, Sanchez C, Shen B. 2001. Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules.
Du L, Sanchez C, Chen M, Edwards DJ, Shen B. 2000. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase. Chem. Biol. 7:623-642.
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Last Modified : 23 October 2007. Copyright © 2007, Cesar Sanchez. |
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